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KMID : 1007520070160050796
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Food Science and Biotechnology
2007 Volume.16 No. 5 p.796 ~ p.801
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Antioxidant and Anti-inflammatory Activities of Allium victorialis subsp. platyphyllum Extracts
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Lee Je-Hyuk
Choi Soo-Im
Lee Yong-Soo
Kim Gun-Hee
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Abstract
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This study was conducted to investigate antioxidant activity and anti-immunological inflammatory effect of Allium victorialis subsp. platyphyllum extracts (AVPEs). Antioxidant activities of AVPEs were determined by free radical scavenging assay and reducing power test. Leaf-part extract had comparatively better antioxidant activity than other-part extracts. Antioxidant activity of extracts had protective effect for human umbilical vein endothelial cells (HUVECs) against superoxide anions secreted from activated neutrophils. Also, we observed AVPEs had inhibitory effects on the adherence of monocytic THP-1 to HUVEC monolayer to the basal level. Inhibitory effect on cell adhesion was caused by suppression of tumor necrosis factor-α (TNF-α)-upregulated expression of vascular cellular adhesion molecule-1 (VCAM-1) and E-selectin in HUVECs. From these results, we expect to support the evidence of anti-immunological inflammatory effects of Allium victorialis subsp. platyphyllum (AVP) as a Korean traditional pharmaceutical.
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KEYWORD
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Allium victorialis subsp, platyphyllum, antioxidant, anti-inflammation, HUVEC, neutrophils, monocyte
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